Plasma half life of some drugs: Drugįactors affecting Half Life: 1. Elimination half life is about 7 to 10 hours. Once it leaves the brain, person regains consciousness but because it is deposited in the tissues, person keeps on feeling drowsy. After administration, the drug immediately goes to the brain, produces its effects, then leaves plasma to get deposited in the tissues. It is administered through intravenous route and has very short duration of action (about 5 to 10 min). Thiopentone sodium us used as a general anesthetic. More the clearance of a drug, shorter is the half life.
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More time is required for their elimination, thus have greater half life. Some drugs have high volume of distribution and are distributed to various tissues, mostly adipose tissue. When the drug is absorbed and reaches the plasma, it is distributed to the tissues. Drugs having beta half life have two half lives, one in the plasma and one in the tissues. Most of the drugs have alpha half life and remain in the plasma. Half life = 0.693 x Vd/ total body clearanceĪlpha half life = plasma / distribution half lifeīeta half life = tissue / elimination half life Half life of a drug is directly proportional to the volume of the distribution and inversely proportional to the clearance. “Time required for the concentration of a drug to fall to half of its initial concentration after reaching its peak.”įor example, after intravenous administration, if maximum concentration is 16 mg and the half life is 2 hours, after 2 hours 8 mg will be left, and so on. Once the level falls below the minimum effective plasma concentration, the effect is over. Drug requires a minimum effective plasma concentration for the effects to start appearing. In case of oral route, plasma concentration gradually rises and reaches its peak value, then it begins to fall down. If you don't think any of the above situations apply, you can use this feedback form to request a review of this block.Onset, duration and intensity of effect of drug depends on the rate of absorption, distribution and elimination (biotransformation, excretion). Contact your IT department and let them know that they've gotten banned, and to have them let us know when they've addressed the issue.Īre you browsing GameFAQs from an area that filters all traffic through a single proxy server (like Singapore or Malaysia), or are you on a mobile connection that seems to be randomly blocked every few pages? Then we'll definitely want to look into it - please let us know about it here. You'll need to disable that add-on in order to use GameFAQs.Īre you browsing GameFAQs from work, school, a library, or another shared IP? Unfortunately, if this school or place of business doesn't stop people from abusing our resources, we don't have any other way to put an end to it.
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